Coffee Science_v.20, 2025
URI permanente para esta coleção${dspace.url}/handle/123456789/14735
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Item Total phenolic content and antioxidant capacity in Muscodor spp. inoculated seedlings of coffee cultivars of Brazil(Editora UFLA, 2025-06-04) Mourão, Bárbara; Bertolucci, Suzan Kelly Vilela; Guimarães, Sarah da Silva Costa; Coelho, Adriane Duarte; Rocha, João Pedro Miranda; Carvalho, Júlia Helena Gomes de; Pedroso, Márcio Pozzobon; Cardoso, Patrícia GomesFungi of the genus Muscodor have received considerable attention for producing volatile and non-volatile organic compounds with biological activity. The objective of this study was to determine the total phenolic content and antioxidant capacity in two coffee cultivars (Catuaí Vermelho and Topázio) inoculated with the endophytic fungi Muscodor coffeanum and Muscodor sp. and in fungal extracts, as well as to characterize the phenolic compounds and trigonelline produced by isolates of Muscodor. Seeds of Coffea arabica (Catuaí Vermelho and Topázio cultivars) were inoculated with twelve fungal isolates and grown in a greenhouse for 24 months. The results showed that the cultivars inoculated with M. coffeanum (CML 4019) had the highest production of total phenolic content and antioxidant capacity. The presence of total phenolic content showed a direct correlation with antioxidant activity. Total phenolic content and antioxidant capacity varied among different Muscodor isolates. The phenolic profile of Muscodor extract determined by HPLCDAD showed the production of catechin, vanillin, and the caffeic, chlorogenic, ferulic, gallic, o-coumaric, p-coumaric, and syringic acids and the alkaloid trigonelline. These endophyte fungi associated with the coffee fruit can improve the quality of the beverage.Item Association Between Black Tea and Coffee Consumption, Socioeconomic Status, and Digestive Disorders: A Case-Control Study(Editora UFLA, 2025-06-04) Asgharzadeh, Vahid; Mahdavipoor, Behroz; Asgharzadeh, Mohammad; Somi, Mohammad Hossein; Hosseini, Mohammad Reza; Ghazani, Hossein Bari; Ozma, Mahdi Asghari; Rashedi, Jalil; Kohkalani, Moein; Rezaei, Seyyed Amin SeyyedThis study aimed to explore the relationship between black tea and coffee consumption and the prevalence of digestive system disorders in the Azeri population of East Azerbaijan, Iran, while considering the influence of underlying social and economic conditions. A case-control study involved 186 patients diagnosed with digestive system disorders and 185 healthy controls. Data were collected via questionnaires that assessed demographic factors, black tea and coffee consumption habits, water intake, and socioeconomic status. We used a rapid urease test to detect Helicobacter pylori infection in the patients. Statistical analyses were performed using the chi-square test, with a p-value less than 0.05 as statistically significant. Black tea and coffee consumption was significantly higher in the patients than in the healthy controls (p < 0.05). Patients also had lower levels of education and financial status. Daily water intake was significantly lower in patients, while consumption of liquids with meals was higher (p < 0.05). Additionally, patients who consumed black tea and coffee after meals had a higher prevalence of digestive disorders. High consumption of black tea and coffee is associated with an increased risk of digestive system disorders, especially among individuals with lower socioeconomic status. These findings suggest that dietary habits, along with underlying social and economic conditions, should be considered when managing digestive health, especially in populations with high black tea and coffee consumption.Item Potential inhibitory action of cafestol on apoptosis proteins: An in-silico study(Editora UFLA, 2025-02-04) Rendón-Rodríguez, Juan José; Lopera-Rodríguez, Jorge Alejandro; Sanabria-Chanaga, Elkin; Röthlisberger, SarahCoffee has been found to reduce cell proliferation and induce apoptosis, which is significant in terms of protecting against cancer. However, the molecular mechanism of this effect is yet to be fully elucidated. The aim of this study was to evaluate the affinity between 12 key proteins involved in apoptosis and four of the main compounds derived from coffee: caffeine, cafestol, caffeic acid, and chlorogenic acid, in order to contribute to the understanding of the effect of coffee on apoptosis. Molecular docking was performed between proteins and ligands using Autodock Tools in Autodock Vina. The best protein-ligand complexes were then submitted to molecular dynamics (MD) simulations in GROMACS 2018.2. The best interactions in molecular docking analysis were Bcl-2 with cafestol, Bcl2l1 with cafestol, and Bax with cafestol. MD simulations show that cafestol binds more strongly within the binding pockets of Bcl-2 and Bax, while the Bcl2l1-cafestol complex is not very stable. These results imply that cafestol competes for binding with Bcl-2 and Bax. Binding of cafestol could inhibit the anti-apoptotic activity of Bcl-2 and promote the pro-apoptotic activity of Bax, thus favoring apoptosis. This is especially relevant in the context of cancer cells, where the expression of Bcl-2 can be increased. We propose a model in which the binding of cafestol with Bcl-2 favors a pro-apoptotic effect, and as such is worth further scrutiny as an anticancer strategy.Item System Dynamic Model of Production Control in Indonesia’s Robusta Coffee Downstream Agroindustry (A case study)(Editora UFLA, 2025-05-19) Herry Purnomo, Bambang; Novita, Elida; Setiawati, Anis; Wahono, Puji; Pradana, Hendra Andiananta; Kurnianto, Mokhamad Fatoni; Pramulya, Rahmat; Rahmah, Devi Maulida; Sutrisno, Adi; Amiluddin, AfifThe small-scale downstream agroindustry of Argopuro robusta coffee often faces problems related to suboptimal production management. The Kahyangan Robusta Coffee Processing Unit (called UPH) produces roasted and ground coffee and has the same problem, often being unable to meet market demand, having excess product and raw material inventory, and quite high production costs. The purpose of this study is to design a system dynamic model for production control that can guarantee the fulfillment of market demand for roasted and ground coffee, reduce excess inventory, and lower production costs. The research results show that until 2025, UPH is still unable to meet market demand (stockout occurs) of 66,25 kg (roasted coffee) and 57,04 kg (ground coffee), product stock volume of 24,6 tons, and total production costs of Rp. 1,34 billion. A policy scenario was developed to handle this unsatisfactory situation by regulating the production rate of roasted and ground coffee through variable settings for the amount of downstream product safety stock, ‘inventory adjustment time’, and ‘time to update demand’. The results of the model simulation show that monthly demand has been met without stockouts. There were savings in production costs of up to 14% and stock reductions for raw materials of 42%, roasted coffee of 14%, and ground coffee of 27,36%. The model has proven to be useful for inventory optimization and cost management. UPH can follow up by controlling the production rate according to the level of downstream product stock so that it can increase its competitiveness.